Wild boar attacks and injures 4 people in Berlin

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Materials scientists make additive-free battery electrodes with nanoparticles

ScienceDaily (Oct. 30, 2012) ? Materials scientists have developed a simple, robust way to fabricate carbon-free and polymer-free, lightweight colloidal films for lithium-ion battery electrodes, which could greatly improve battery performance.

By developing a method for additive-free electrodes that maintain high conductivity, the researchers have opened new possibilities for reducing the weight and volume of batteries, while also creating a template system for studying the physics of nanoparticle electrodes.

The work, led by Richard Robinson, assistant professor of materials science and engineering, and graduate student Don-Hyung Ha, is featured in the Oct. 10 issue of Nano Letters (Vol. 12, No. 10).

Nanoparticles have been extensively investigated as an active cathode and anode in lithium-ion batteries -- common components of electronic devices -- because they can enhance the batteries' electrochemical properties.

To use colloidal nanoparticles for the electrodes, it had been necessary to combine them with carbon-based conductive materials for enhancing charge transport, as well as polymeric binders to stick the particles together and to the electrode substrate, Robinson said. This process added extra weight to the battery and made it difficult to model the movement of Li-ions and electrons through the mixture.

The critical processing technique Robinson and colleagues used was electrophoretic deposition, which binds the metal nanoparticles to the surface of the electrode substrate to each other in an assembly, creating strong electrical contacts between the particles and current collector.

The process results in a significant improvement in battery electrode assembly that cannot be replicated by conventional methods. Once attached, the particles are no longer soluble and are mechanically robust. In fact, this processing creates a film that has superior mechanical stability when compared to films fabricated by conventional battery-making methods with binders, Robinson said.

This research has led to the first cobalt-oxide nanoparticle-film battery electrode made without using binders and carbon black additives, and they show high gravimetric and volumetric capacities, even after 50 cycles.

The work was supported by the Energy Materials Center at Cornell funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Science; the Cornell Center for Materials Research with funding from the National Science Foundation; and by the King Abdullah University of Science and Technology center at Cornell.

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The above story is reprinted from materials provided by Cornell University. The original article was written by Anne Ju.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Don-Hyung Ha, Mohammad A. Islam, Richard D. Robinson. Binder-Free and Carbon-Free Nanoparticle Batteries: A Method for Nanoparticle Electrodes without Polymeric Binders or Carbon Black. Nano Letters, 2012; 12 (10): 5122 DOI: 10.1021/nl3019559

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/wZ9pWrGP6K0/121030173123.htm

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Happy Halloween! Give Wednesday’s spook-tacular links a click: Chinese think tank urging end to “one-child” policy – NPR How to handle when a hurricane and a holiday collide – Wall Street Journal Surviving baby’s first flight – lilSugar.com Michelle Obama on getting her daughters to behave in public – New York Daily News What food [...]

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/TCDm1dvxyjU/

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Eateries facing a plate of health care issues | Atlanta Forward

Moderated by Rick Badie

Higher menu prices. Fewer work hours and jobs. Zero expansion and possible closings. This, writes a local franchiser, will be the potential impact in the restaurant industry of health mandates under the Affordable Care Act. But the co-founder of a workers? advocacy group suggests that businesses can profit by taking care of personnel.

Repeal Obamacare

By Aziz Hashim

More than three years into our jobless ?recovery,? 12.1 million Americans are still out of work. Nearly 23 million have stopped looking or can?t find full-time work.

The labor participation rate is 63.6 percent, the same level we saw in 1981. Employers are only adding slightly more jobs per month needed to keep pace with normal labor-force expansion.

So why did the unemployment rate go down below 8 percent last month? In large part, due to an increase in part-time work. While the drop in unemployment may seem completely positive, there is an underlying problem for small business owners due to Obamacare.

As employers begin to make their growth plans for the next year, the true costs of Obamacare have started to sink in. They threaten much of the growth forecast in businesses like mine, a franchise of pizza, burger and chicken restaurants that include Atlanta-based Popeyes Louisiana Kitchen. I want to grow my business and add more locations. Obamacare penalizes me every time I add a full-time worker to my franchise.

The employer mandate forces employers to provide coverage or pay a penalty once they reach the 50 full-time-employee threshold. Employers face a decision of closing a business, eliminating jobs, or shifting workers from full- to part-time to avoid the law?s penalties. We are likely going to choose the latter option.

In the franchise industry, there are thousands of multi-unit franchises like me who are put at a competitive disadvantage by the law?s employer mandate. This threatens growth in our industry. In cases where a franchisee owns and operates multiple locations, the law treats these firms as one company for tax and health-care purposes.

Suppose a multi-unit franchisee owns four establishments with 15 full-time employees each. Under the law, this multi-unit franchisee will be treated as a single firm with 60 full-time employees. The employer will be required by law to provide health care benefits for all employees or pay a fine of $2,000 per full-time employee per year. If these four establishments were owned and operated separately, they would be exempt from the health care requirement.

If these four separately owned businesses choose to offer health insurance, they would in many cases be entitled to a tax credit, making this an even further disadvantage for multi-unit ownership.

Businesses cannot operate at a loss for an extended time. That is the choice this law may force companies to face. Another often-overlooked factor is that many businesses will have an added incentive to become more automated and employ fewer workers. Utilizing automated check-out counters and purchasing new machinery are options we must consider to reduce the number of employees and remain profitable under these mandates.

Business owners like me who want to continue to expand would feel more confident about expansion and hiring plans without Obamacare. The only way to change this is by repealing Obamacare in its entirety and starting over with market-based solutions.

Aziz Hashim is president and CEO of? Decatur-based National Restaurant Development, Inc.

Health care can help stabilize workforce

By Saru Jayaraman

There?s been a lot of talk about the recent announcement by Darden, the world?s largest full-service restaurant company and owner of Olive Garden and Red Lobster, that it would reduce workers? hours to avoid having to provide health coverage when the Affordable Care Act goes into effect in 2014.

None of the coverage mentioned the impact on one key stakeholder group: consumers.

Last fall, a server at a North Carolina Olive Garden was forced to work with Hepatitis A because the company neither offers paid sick days nor any kind of health care. Three thousand people had to get tested for Hepatitis A and many ended up winning a consumer class-action lawsuit against the company.

The Affordable Care Act (ACA) is a great step to ensure that people who touch our food are not sick, making sure that we don?t get sick as well. Darden claims the ACA is forcing the company to reduce its employees? hours to stay afloat.

Moreover, the National Restaurant Association would have you believe the industry is going to collapse if it actually provides workers with genuine health-care access. There are plenty of great employers in America already providing benefits.

For the last three decades, Zingerman?s Community of Businesses in Michigan has been providing up to 80 percent of workers? health care premiums on a comprehensive health care plan. Zingerman?s started as a two-employee deli in 1982. It has grown to an award-winning company with nine businesses that employ 575 workers and realize more than $40 million per year in revenue.

How? Zingerman?s was committed to working benefits into its business model from the start and heard workers? input in choosing the plan.

Says Zingerman?s founder Paul Saginaw, ?What do you get from it? You get a stable workforce. You get a workforce that can stay healthy. You get someone who feels good about the company and is out there trying to help the company be successful. The benefits are enormous. So now you figure out how to make it work.?

Everyone agrees health care costs are high. Saginaw believes a government-funded plan would be best. Without that, Saginaw needs and wants his employees to be healthy, for the sake of his workers and customers, and for his own bottom line. His workers say their customer service is better because they feel secure.

In fact, restaurants in the whole city of San Francisco have had to contribute toward a health care fund for their workers since 2008. Business is booming.

The organization I direct, Restaurant Opportunities Centers United, puts out a consumer guide on which restaurants provide benefits like paid sick days and which don?t at www.rocunited.org/dinersguide. We should support restaurants that do and let others know they shouldn?t cut corners because we put our health in their hands every time we eat out.

Saru Jayaraman is co-director of Restaurant Opportunities Centers United in New York.

Source: http://blogs.ajc.com/atlanta-forward/2012/10/30/eateries-facing-a-plate-of-health-care-issues/?cxntfid=blogs_atlanta_forward

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Photos: Sandy slams the East Coast

Vehicles are submerged during a storm surge near the Brooklyn Battery Tunnel, Monday, Oct. 29, 2012, in New York. Superstorm Sandy zeroed in on New York's waterfront with fierce rain and winds that shuttered most of the nation's largest city Monday, darkened the financial district and left a huge crane hanging off a luxury high-rise. (AP Photo/John Minchillo)

Vehicles are submerged during a storm surge near the Brooklyn Battery Tunnel, Monday, Oct. 29, 2012, in New York. Superstorm Sandy zeroed in on New York's waterfront with fierce rain and winds that shuttered most of the nation's largest city Monday, darkened the financial district and left a huge crane hanging off a luxury high-rise. (AP Photo/John Minchillo)

Source: http://news.yahoo.com/photos/hurricane-sandy-1351517288-slideshow/

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Presidential race rained out even in sunny states

People brave high winds and blowing sand as they walk on Steeplechase Pier at Coney Island in the Brooklyn borough of New York as Hurricane Sandy arrives, Monday, Oct. 29, 2012. Hurricane Sandy continued on its path Monday, as the storm forced the shutdown of mass transit, schools and financial markets, sending coastal residents fleeing, and threatening a dangerous mix of high winds and soaking rain. (AP Photo/Mark Lennihan)

People brave high winds and blowing sand as they walk on Steeplechase Pier at Coney Island in the Brooklyn borough of New York as Hurricane Sandy arrives, Monday, Oct. 29, 2012. Hurricane Sandy continued on its path Monday, as the storm forced the shutdown of mass transit, schools and financial markets, sending coastal residents fleeing, and threatening a dangerous mix of high winds and soaking rain. (AP Photo/Mark Lennihan)

Lisa Famularo braces for impact as a large wave crashes over a seawall while she photographed heavy surf in the Atlantic Ocean during the early stages of Hurricane Sandy, Monday, Oct. 29, 2012, in Kennebunk, Maine. Hurricane Sandy continued on its path Monday, as the storm forced the shutdown of mass transit, schools and financial markets, sending coastal residents fleeing, and threatening a dangerous mix of high winds and soaking rain.?(AP Photo/Robert F. Bukaty)

DENVER (AP) ? Crista Laughlin was a mile high and dry, but Superstorm Sandy still kept the 40-year-old Obama campaign volunteer from walking precincts or working the phones.

Instead, she was huddled inside her suburban Denver home, watching storm coverage on television and thinking about her grandson in Norfolk, Va., in the hurricane's path. "I'm actually with the president on this one: The election will take care of itself in a week. What's on our minds is the people," said Laughlin, a 40-year-old volunteer in Aurora, Colo.

The presidential election was, well, rained out Monday ? from the media centers and storm-battered battleground states of the Atlantic coast to the arid, high plains suburbia of Colorado. Republican vice presidential candidate Paul Ryan canceled three Colorado appearances scheduled for Tuesday as the Romney's campaign announced it was suspending political events featuring the top of its ticket. Meanwhile, President Barack Obama scrapped his own Tuesday appearances ? including one in Colorado ? and fled a Monday morning rally in Florida to make it back to the White House before the storm.

The president's campaign emailed supporters urging them to donate to charities that help storm victims. In Romney campaign offices, volunteers cut into their phone-banking and door-knocking time to stockpile canned goods to send to the disaster zone. The storm gave Obama a chance to appear presidential during a national emergency, and challenger Mitt Romney a potential opening should the federal government botch the response.

It also had a political impact thousands of miles away, giving people like Roger Draeger a break.

The 75-year-old funeral driver from Fort Atkinson, Wis., is a Romney supporter, but he was glad both candidates suspended their campaigns Monday. It was a blessed reprieve from the nonstop political debate that has dominated Wisconsin since Gov. Scott Walker signed a bill limiting collective bargaining for state workers last year, triggering a long series of recall elections.

Still, like other residents of this poll-obsessed nation, Draegar quickly began to analyze the upsides and downsides for each candidate, saying both should be visible in the aftermath. Obama "really needs to show a lot of compassion for all those states and cities," he said.

It's a sign of how thoroughly the campaign has permeated swing-state life that Dan Guimond, 61, an economist in Denver, was partly getting his hurricane updates through the political-junkie website Real Clear Politics and The New York Times blog FiveThirtyEight. Guimond is worried about his parents, who live in Massachusetts, but not worried about how the storm could affect the race. "Obama canceled his, what, 26th trip to Colorado? Big deal," he said.

A modicum of politics still continues here. Former President Bill Clinton and Jill Biden, the vice president's wife, were still slated to campaign in Colorado on Tuesday, and the Romney campaign sent the candidate's son Craig to an early vote event Monday afternoon. The president, notably, is scheduled to return to Colorado Thursday. Still, some of his supporters said they may not be able to do as much for him.

Mitt Romney held what his campaign called a "storm relief event" in Ohio Tuesday. His wife, Ann, will help gather donations at campaign offices in Wisconsin and Iowa Tuesday before a Des Moines, Iowa, rally. The Romney campaign also announced Ryan will drop by a donation drive in Wisconsin.

Denver Pastor Leon Emerson, head of the Greater Metro Denver Ministerial Alliance, spent the weekend rallying voters for Obama with actor Laurence Fishburne. But he expects Sunday talks at church to focus less on the upcoming election and more on the storm.

"I'll eventually talk about the election, but I may not put as much emphasis on it, depending how this hurricane turns out," Emerson said. "Politics is one thing, but you know what? We're going to keep our attention on helping mankind."

Emerson said his congregation is shifting focus, too.

"We had some plans today and tomorrow, going door to door. It's still going on, but not with the intensity we had, because people want to make sure their loved ones are OK," said Emerson, who has a niece in Hampton, Va.

Some weary swing state voters didn't think the political lull would mean much. "I'm sure the TV commercials aren't going to stop," said Mike Beauregard, a Republican-leaning Independent who owns a cooking utensil shop in Concord, NH.

Others were fixated on images of the storm but still saw the devastation through the prism of the election. In western Wisconsin, at the bustling student union at the University of Wisconsin in River Falls, a television tuned to cable news showed ominous images of the storm. History major Mike Engelhardt, 21, said Obama had the most on the line.

"If he bungles the beginning of the cleanup, that will move a lot of votes to Romney," Engelhardt predicted.

One place the storm may have an impact is North Carolina, where Democrats are hoping new voters who cast their ballots early will overcome the GOP's traditional Election Day advantage at the polls. Rain from the storm shuttered some early voting locations Sunday, and election officials were concerned that heavy snow in the western mountains could make it even harder to get to polling places early.

"The weather could chill participation," state election executive director Gary Bartlett said.

Democrats are counting on running up an edge in early votes in other swing states as well ? ones that lie outside the storm's path but were still on the minds of Romney supporters in sunny Davenport, Iowa, where the Republican candidate made a final Monday afternoon appearance.

Tim Vath of Dubuque said he didn't think the storm would fundamentally disrupt the election. But he did worry that any bad weather now might increase the magnitude of any early-voting advantage Democrats might have.

"Perhaps it could freeze that advantage in place. I doubt it would determine the outcome in those states," said Vath. "At least, I hope not."

As Sandy rumbled past the tiny Chesapeake Bay hamlet of North, Va., William Sullivan, 76, swung by the town's main building, which holds the post office, bait shop and convenience store. Sullivan trashed two-thirds the mail stuffing his post office box, mainly glossy political brochures from both sides.

"Makes me sick to my stomach thinking of the millions of dollars these characters have spent to get elected," Sullivan said before heading back out into the rain. He doubted the dramatics surrounding the storm would change the minds of his rural neighbors. "People have their minds made up," he said.

In downtown Denver, it was sunny and in the 60s as Jeremy LeVal, a Romney supporter, waited at a bus stop. He confessed he has paid limited attention to both the campaign and the storm. He knew the hurricane was bearing down on the Northeast and hoped there was no major damage, but doubted the brief suspension of the presidential contest would matter.

"If people haven't decided at this point," LeVal said, "it probably won't make a difference."

___

Associated Press writers Bob Bakst in River Falls, Wis., Tom Beaumont in Davenport, Iowa, Norma Love in Concord, N.H., Stephen Ohlemacher in Washington, Todd Richmond in Waunakee, Wis., and Bob Lewis in North, Va., contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-10-30-US-Presidential-Campaign-Superstorm/id-e7c27c631c54447883bcc5db7b4651c7

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VanEats Dining Pass ? ?Whet Your Appetite? - Modern Mix Vancouver

Whet Kitchen.Bar.Patio has been open on Granville Island for about a year and a half and serves West Coast inspired dishes. ?They are currently offering a promotion on behalf of VanEats.ca for a $30 set-menu dining pass which includes two appetizers, one main course and two sleeves of beer.

Our dinner at Whet Kitchen Bar Patio?started off with the ?Prawn, Shrimp, & Wild Mushrooms Salad? which consists of pan seared prawns, hand peeled shrimp?and wild local mushrooms on?a bed of arugula drizzled with a lemon-hazelnut vinaigrette. ?I loved how the little shrimp and mushrooms were warm and savory and provided a delicious contrast to the slightly tart and peppery arugula.

Next up was the ?Coconut Scallop Ceviche? which was a beautiful work of art presented in a glass tumbler. ?I was surprised at how many little shrimp fit into the glass because each time I spooned the mixture, I was always able to get a few shrimp or bits of scallop onto my spoon. ?The ceviche came with corn chips; it was?a bit messy to eat ?because the ceviche was quite drippy and watery.

For the main course, I ordered the duck with sweet chilli ginger sauce. ?I thought the duck was a bit too salty for my taste, and I didn?t really notice the sweet chilli ginger sauce. ?But nonetheless, similar to all the other dishes I?ve had so far, the presentation of the dish was carefully crafted. ?The yam and plantain chips were balanced carefully on the duck at various angles ? it was a surprise to me that it didn?t all topple down!

Chances are, you are dining with a guest. ?If you have the VanEats.ca Whet Your Appetite pass, your guest can order another main course (either the duck or the Coho salmon) for only $15, which is pretty much cheaper than any other main course on the menu. ?The??Red Honey-Curry Coho? came with saffron yoghurt, hot pickled lime puree, candied almonds and?broccolini.

To accompany your food, the VanEats.ca dining pass includes two sleeves of Russell Brewing Company?s Angry Scotch Ale, which is a smokey, dark ale that originated in Edinburgh.

To eat the same meal I did at Whet Kitchen.Bar.Patio, head to?vaneats.ca,?purchase a dining pass for $30 and get ready to ?whet your appetite?!.

Source: http://modernmixvancouver.com/index.php/2012/10/28/vaneats-dining-pass-whet-your-appetite/

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Dishonored Trophies and Achievements guide Part 1 | Video Game ...

Released just a couple week ago, the first person game Dishonored is definitely one of a kind: it?s more akin to an action-adventure game rather than a first person shooter since players can freely choose how to overcome each and every obstacle. You can read more on our review of the game.

The Trophies and Achivements for Dishonored are not too hard to obtain: you can get quite a few without even trying while others require a bit more of attention, with a couple that can be easily missed. Obviously there?s gonna be some spoilers in this guide so read at your own risk if you haven?t completed the game yet. In the first part of the guide will tackle all story related trophies ? achievements, the endings and secondary objective ones.

Story related Trophies ? Achievements

• Dishonored
• Excommunication
• Child Care
• Capturing Genius and Madness
• Regicide
• Political Suicide
• This is Mine
• Resolution

You?ll get these trophies/achievements by just playing through the game at any difficulty level.

Ending related Trophies ? Achievements

• Dunwall in Chaos
• Just Dark Enough

These two trophies need to be unlocked in two different playthroughs: they?re for completing the game in High Chaos or Low Chaos. To reach High Chaos you have to kill as many as you can, to reach low chaos you have to kill as little as possibile. You?ll understand if you?re in either state during the ninth mission: it?s going to take place in daylight if you?re in low chaos, nightime with rain and thunders if you?re in high chaos. After watching the ending the corresponding trophy ? achievements will unlock.

Specific objectives Trophies ? Achievements

You?ll get these trophies by accomplishing secondary tasks in some mission which I?ll detail under the trophy ? achievement name.

You?ll get this trophy by protecting Callista?s at Hound Pit?s Pub, There are a few ways to do it: crashing the conversation, knocking Geoff off and hide him in a dumpster or follow Geoff and the High Overseer and save Geaoff before the High Overseer stabs him.

You need to spare Daud?s life: he?s the assassin who killed the empress and the man who?ll throw away all your stuff on mission 7.
You?ll have to get his key to escape so you can?t miss him. Simply don?t kill him during the key?s retrieval.

This can be earned on mission 9 and the method to obtain it will vary if you are in high or low chaos. In low chaos it is unmissable since the objective is to save the empress and she?s locked in a room; in high chaos things will be a bit more complicated: near the lighthouse you?ll find and enemy holding the empress near an edge and if you move forward or waste too much time the empress will fall and die. Simply kill the enemy before he can do so: I did it by using time bending.

To get this trophy you?ll have to complete the missions given to you by Grannt Rags during mission 2. High Overseer Campbell will tell you about her so it?s really hard to miss her.

You have to complete all Slackjaw?s side missions during mission 3 for this trophy. He?s close to where Granny Rags was in mission 2 so he?s hard to miss as well.

In the next part we?ll tackle more trophies-achievements, including the hardest to get like the steal oriented ones.

Stay tuned, part 2 will come very soon!

?

Article from Gamersyndrome.com

Related posts:

1. Assassin?s Creed II: Trophies & Achievements Guide
2. Final Fantasy XIII (13) Guide: Achievements / Trophies
3. Borderlands 2 ? Trophies & Achievements
4. Three New DLC Packs Planned For Dishonored
5. Here Are (Most of) Final Fantasy XIII?s Trophies

Source: http://gamersyndrome.com/2012/video-games/dishonored-trophies-guide-part-1/

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November Food Calendar Sneak Peek! | Ate by Ate

So, why the sneak peek of the November Food Calendar while it?s still a work in progress?? Let?s just say you?ll want to snatch up a ticket for some of these events sooner rather later!? Some of these events have a limited amount of tickets and since several of these take place during the first half of the month, posting these an extra few days in advance just might save you a little heartbreak!? Yes, I?m looking you, you burger/chocolate/wine lovers!? Read on for the goods!

Toronto Chocolate Festival 2012: Chocolicious, October 13-November 4.? Various times and locations; check the Chocolicious passport in the link below for all participating locations!? As part of the Toronto Chocolate Festival, Chocolicious offers everyone a rich, decadent taste of some of the finest chocolates, and chocolate pastries and desserts.? Various chocolatiers and patisseries around the city participate in this event by offering coupons, discounts, and special event promotions via the Chocolicious Passport, which chocolate lovers can download and present when they visit participating locations.? http://www.torontochocolatefestival.com/events/chocolicious

Toronto Chocolate Festival 2012: Chocolate High Tea, October 13-November 4 (Fridays and weekends only).? 2:30pm-5pm.? 37 King Street East at the King Edward Skyline Hotel.? $33-$55 +HST/person.? As part of the Toronto Chocolate Festival, the King Edward will be hosting this year?s chocolate high tea!? Indulge in a chocolate inspired afternoon tea menu with loose leaf teas, pastries, desserts, and savoury bites.? http://www.torontochocolatefestival.com/events/chocolate-high-tea

Winterlude at Steam Whistle Brewery, November 2.? 6:30pm-11:30pm.? 255 Bremner Blvd. at Steam Whistle Brewery.? $35/person; must be 19+ years of age to attend.? In support of the Ontario Track 3 Association for the Disabled, Winterlude at Steam Whsitle Brewery will gear you up for the upcoming winter season with carnival games and mechanical snowboard rides, music, silent auctions, and plenty of food and drink to keep you warm!? Brewery tours, finger foods, product booths, sample booths, and more!? http://www.track3.org/innerpage.aspx?x=EdU2leiPwBsW3kxLgxbig5SNEqO746zzeoaRAHIswb4hAlyASiznwwozOF09BP1i

The Royal Agricultural Winter Fair, November 2-11.? 9am-9pm Monday to Saturday, 9am-9pm Sunday November 4, 9am-6pm Sunday November 11; check schedules and listings on the fair?s website below for specific show times.? 100 Princes? Boulevard and Exhibition Place grounds.? For almost a century, the Royal Agricultural Winter Fair has dazzled visitors with its world class equestrian competitions and horse and agricultural shows, dining, shopping, and more.? The fair celebrates its 90^th year this year with numerous culinary delights including the royal wine competition, wine tastings dinner, mixology competition, chef challenges involving some of Food Network Canada?s most beloved chefs and personalities, butter sculpting, and so much more!? See calendar listings below for more specific event details.? http://www.royalfair.org/

D?a de los Muertos at Evergreen Brick Works, November 3.? 8am-2pm.? 550 Bayview Ave at Evergreen Brick Works Pavilions.? FREE; cost of food and drink on-site.? Come and celebrate Mexican and Latin American culture, history, and tradition at the Brick Works with art, crafts, music, and FOOD!? Eat to your heart?s content from a number of Mexican and Latin American vendors at the farmers? market including ChocoSol, Pancho?s Bakery, Agave y Aguacate, Oxala, and others serving sweet and savoury baked goods, street food, and more!? And, for $6, take part in a special sweet and savoury tamales competition where you?ll taste and vote on the goods of 4 Toronto chef participants!? http://ebw.evergreen.ca/whats-on/special-events/dia-de-los-muertos

Ice, Wine & Dine, November 3.? 4pm-10pm.? Street festival on Elm Street and around the Yonge-Dundas area.? FREE; cost of food and drink on-site as well as $5 sampler menus from participating restaurants.? As part of Toronto?s Downtown Yonge Winter Magic festival, Ice, Wine & Dine is back for another year!? Embrace the upcoming winter season with a cocktail street party in the heart of downtown Toronto!? Enjoy martinis and cocktails at the Ice Martini Lounge, seasonal wine tastings, and sampler menus from 12 different restaurants in the area.? Ignite the senses at this fun and fabulous winter wonderland culinary event!? http://www.wintermagic.ca/icewinedine

Nth Lounge & Emporium, November 3.? 11am-9pm for general admission (10am for VIP entry which includes continental breakfast along with general admission amenities).? 1214 Queen Street West at the Gladstone Hotel, 2^nd floor lounge.? $25 for general admission, $30 for VIP entry; must be 19+ years of age to attend.? Mix luxury with shopping, pleasure, relaxation, wine, sweets, and cupcakes at this exclusive event at the Gladstone Hotel.? Nth Lounge & Emporium brings experiences such as shopping, art, spa, and food together under one roof with their events and product shows.? Enjoy complimentary wine and cupcake tastings as well as tea and a sweets bar.? http://www.nthlounge.com/tickets.html

Toronto International Luxury Chocolate Show, November 4.? 11am-6pm.? 60 Simcoe Street at Roy Thomson Hall.? $25/person (13+) at the door; $21/person (13+) on-line; $15/child ages 5-12 when accompanied by an adult (tickets only available at the door); FREE for children 4 and under accompanied by parent.? NOTE: strollers are not permitted on show grounds.? Immerse yourself in the luxurious, decadent world of chocolate as you taste and sample your way through hundreds of vendors and chocolatiers, engage in chocolate-making workshops and demos, learn about the history of chocolate and chocolate-making practices, purchase chocolates and chocolate products, and sip on wines at wine and chocolate tastings!? http://www.torontochocolateshow.com/index.html

Food 4 Thought ? A Taste of India, November 9.? 7pm-9pm.? 631 Crawford Street at the Kadampa Meditation Centre Canada.? $20/person or $35 for two.? Enjoy a relaxing evening meditation session in the temple before sitting down to a special 3-course vegetarian meal prepared by volunteers, focused on building, feeding, and maintaining a healthy mind, body, and soul.? At this Food 4 Thought session, the flavours of India are showcased.? http://kadampa.ca/event/food-for-thought/

Mariposa?s Holiday Dinner Cruise, November 10.? 6:30pm-10:30pm.? 6:30pm boarding time.? 207 Queens Quay West at the Queens Quay Terminal.? $72.95 +fees and taxes.? Celebrate the holiday season in culinary style at one of Mariposa?s holiday dinner cruises on Toronto?s harbour!? Menu items include shrimp and scallop pasta, roast turkey, prime rib of beef, winter root vegetables, Mediterranean dips and breads, and so much more!? Enjoy a festive evening and a grand winter wonderland buffet dinner on a beautifully decorated cruise ship.? http://www.mariposacruises.com/cruises-special-events.php

Gluten Free Garage at Wychwood Barns, November 11.? 10am-4pm.? 601 Christie Street at Artscape Wychwood Barns.? $10/person, FREE for children 12 and under.? Pay-at-the-door, cash only.? With over 40 different vendors, Gluten Free Garage is Toronto?s very first pop-up gluten-free marketplace showcasing everything from gluten-free lifestyle, nutrition, and food!? Sample and taste your way through this extraordinary event and take away valuable information for eating and living well, gluten free.? Learn about shops, restaurants, and services around the city that offer gluten-free food and products, shop for products, eat gluten-free meals prepared by local chefs, and more.? A portion of the proceeds from the event will go to the Canadian Celiac Association.? http://glutenfreegarage.ca/

Gourmet Food & Wine Expo, November 15-18.? 6pm-10pm Thursday (VIP preview), 2pm-10pm Friday, 12pm-10pm Saturday, 12pm-6pm Sunday.? 255 Front Street West at the Metro Toronto Convention Centre, North building.? $40/person 19+ for VIP preview evening ticket on Thursday, $20/person 19+ for general admission Friday-Sunday.? The annual food and wine show is back for another year with plenty of food and drink to tantalize the tipple!? Sample from hundreds of wine, beer, spirits, and global and local cuisine food and drink vendors, explore the Fine Wine Tasting Lounge, see Food Network Canada chefs and stars, watch demos and more at the All You Need is Cheese Stage, and much more!? http://www.foodandwineexpo.ca/sitepages/

Holiday Craft & Bake Sale, November 17.? 9:30am-1pm.? 1 Overland Drive at the Better Living Health & Community Centre.? FREE; cost of goods on-site.? Do some holiday shopping, support local crafters and artists, and enjoy some fresh, homemade baked goods while you do it!? http://wx.toronto.ca/festevents.nsf/591df5f4e9bb95b0852572ff00502015/11105aa18a7b546385257a98006d0f3c?OpenDocument

Mariposa?s Holiday Dinner Cruise, November 17.? 6:30pm-10:30pm.? 6:30pm boarding time.? 207 Queens Quay West at the Queens Quay Terminal.? $72.95 +fees and taxes.? Celebrate the holiday season in culinary style at one of Mariposa?s holiday dinner cruises on Toronto?s harbour!? Menu items include shrimp and scallop pasta, roast turkey, prime rib of beef, winter root vegetables, Mediterranean dips and breads, and so much more!? Enjoy a festive evening and a grand winter wonderland buffet dinner on a beautifully decorated cruise ship.? http://www.mariposacruises.com/cruises-special-events.php

Tea for Teens Fundraiser, November 20.? 11:30am-3pm.? 1 Colonel Samuel Smith Park Drive at the Lakeshore Community Cultural Centre, Assembly Hall.? Cash donation of $25-$50 or a gift card suitable for a tween or teen.? Show the spirit of giving at this fundraising tea event organized by the Junior League of Toronto in support of underprivileged youth this holiday season.? The event, which has assisted a number of charitable organization make a difference in the lives of teens, especially during the holiday season, will incorporate raffles, a tea, music, shopping, and a live fashion show.? http://www.jlt.org/

Burger Broads Burger Ball, November 22.? 8:30pm-11pm.? 364 Danforth Ave. at Burger Stomper Burger Bar.? $45 +$3.69 fee/person ages 19+.? Tickets are limited.? Enjoy all things burger at this first-ever Burger Broads vegetarian food bank fundraiser!? The Burger Broads (a passionate club of women in Toronto who are dedicated to burgers in all their bun and patty glory) report on everything meatatarian and vegetarian when it comes to burgers and to celebrate this passion, the group is hosting this special fundraising event in support of the Ontario Vegetarian Food Bank.? Meet fellow burger lovers and enjoy great music! ?Meet their broads behind the burger!? Eat sliders and mini burgers as you drink from Steam Whistle Brewery!? And best of all, help out a great cause!? http://burgerbroadsburgerball.eventbrite.ca/

2012 Ukrainian Christmas Bazaar, November 23-24.? 11am-8pm Friday, 10am-7pm Saturday.? 135 LaRose Ave. at St. Demetrius Church Hall at Eglinton & Royal York Rd.? FREE; cost of food, drink, and goods on-site.? This annual Christmas show is back for another year with plenty of arts, crafts, shopping, and food!? Feast on baked goods, chocolate and confectionery, jams and jellies, deli, and traditional Ukrainian cuisine including borscht, cabbage rolls, perogies and more!? http://www.stdemetrius.org/

Mariposa?s Holiday Dinner Cruise, November 24.? 6:30pm-10:30pm.? 6:30pm boarding time.? 207 Queens Quay West at the Queens Quay Terminal.? $72.95 +fees and taxes.? Celebrate the holiday season in culinary style at one of Mariposa?s holiday dinner cruises on Toronto?s harbour!? Menu items include shrimp and scallop pasta, roast turkey, prime rib of beef, winter root vegetables, Mediterranean dips and breads, and so much more!? Enjoy a festive evening and a grand winter wonderland buffet dinner on a beautifully decorated cruise ship.? http://www.mariposacruises.com/cruises-special-events.php

Cooking Classes, Demonstrations, and Seminars

GE Caf? Chefs Series: French Cuisine with Local Allure ? Celebrating Southern Ontario Terrior at Evergreen Brick Works, November 6.? 6pm-9pm.? 550 Bayview Ave.? $75 each workshop.? Learn tips and techniques from local Toronto and Ontario chefs, discuss and explore food issues over wine and a great meal with other participants!? Funds raised through the series will help support children?s educational food programs at Evergreen Brick Works.

This fall series focuses on the food culture of southern Ontario.? Join French chef and owner of French bistro, Mogette, Daniel Muia in this workshop devoted to examining and exploring French gastronomy, cultural food heritage, and classics and how these flavours have translated in Toronto.? http://ebw.evergreen.ca/whats-on/food/chefs-series#nov6

GE Caf? Chefs Series: Pasta Party ? Celebrating Southern Ontario Terrior at Evergreen Brick Works, November 13.? 6pm-9pm.? 550 Bayview Ave.? $75 each workshop.? Learn tips and techniques from local Toronto and Ontario chefs, discuss and explore food issues over wine and a great meal with other participants!? Funds raised through the series will help support children?s educational food programs at Evergreen Brick Works.

This fall series focuses on the food culture of southern Ontario.? Join Chef Fabio Bondi, co-owner of Toronto?s Local Kitchen & Wine Bar and Bar Salumi, in this workshop devoted to examining and exploring homemade pasta making, the role pasta making plays in the home in familial relationships and in Italian food culture, and Italian cuisine.? http://ebw.evergreen.ca/whats-on/food/chefs-series#nov13

Green Bites Cooking Workshops ? Total Mexico at Evergreen Brick Works, November 15.? 7pm-9pm.? 550 Bayview Ave.? $55/person.? Green Bites workshops are back for another exciting round of seasonal classes!? Join chefs, producers, farmers, and food experts for some hands-on cooking workshops that are sure to expand your breadth of food knowledge and technique.? These cooking workshops will allow participants to explore tastes, flavours, and aromas while engaging in food issues that affect communities.

At this workshop, join Chef Francisco Alejandri on this whirlwind Mexican culinary tour of culture and heritage.? Learn about the basic tenants of Mexican cuisine, traditional Mexican dishes and ingredients, and explore and enjoy menu items such as ceviche tostadas, chicken mole, Carlota de Limon (Lime Charlotte)!? http://ebw.evergreen.ca/whats-on/food/green-bites#nov15

Green Bites Cooking Workshops ? Fish From Around the World at Evergreen Brick Works, November 29.? 7pm-9pm.? 550 Bayview Ave.? $55/person.? Green Bites workshops are back for another exciting round of seasonal classes!? Join chefs, producers, farmers, and food experts for some hands-on cooking workshops that are sure to expand your breadth of food knowledge and technique.? These cooking workshops will allow participants to explore tastes, flavours, and aromas while engaging in food issues that affect communities.

At this workshop, join Kristin Donovan, co-owner of Hooked Inc., on this global tour of fish and ethnic flavour!? Fish is incredibly versatile and at this workshop, participants will explore how different ethnic and international cuisines utilize different cooking methods and different types of fish in some of their most iconic, traditional dishes and all the different flavours that play into them.? Feast on menu items such as ceviche (Peru), gravlax and cured salmon (Sweden), traditional chowder (Atlantic Canada), whole steamed fish (Asia), and tandoori fish (India). http://ebw.evergreen.ca/whats-on/food/green-bites#nov29

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Source: http://atebyatescrapbooking.wordpress.com/2012/10/28/november-food-calendar-sneak-peek/

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Social Media is the ?Bottom Line? | StAug News

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21^st Century Businesses KNOW That Social Media is the ?Bottom Line?

Digital Marketing

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Be First, Inc. is the social media team that businesses are choosing because of their knowledge and skill when it comes to brand management and being able to offer the right help when it comes to building a client list ? not to mention the added ability of being able to monitor your company 24/7 (including your competitors) in order to increase your company?s ROI. In fact, Be First is the necessary ?bottom line? to making a company successful.

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This week a series of articles introduce the various forms of digital marketing and advertising that is a necessity in 2012 to increase revenue. From online interactive ads to viral videos to the huge explosion of mobile apps and mobile advertising, social media and digital marketing has allowed corporations to become ?fresh? and new, and has allowed the newest companies in all industries to make a name for themselves and their brand.

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Digital marketing and the power it provides, is something that any social media team knows all about. Many companies are still struggling to understand every facet from banner advertising to search engine optimization, yet what they need to learn is that a social media team must be brought on board that knows the basic fact that there is far more to digital marketing than meets the eye. From blogging to pod casting to voice broadcasts; video streams to instant messaging ? digital marketing is an ocean of information that a business owner must be walked through from start to finish.

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The words ?traditional marketing? have clearly been going out the window for quite a while now. With the exception of the hit TV show, Mad Men, traditional marketing and advertising are no longer even on the company plan to brand themselves and their products. Billboards, print ads ? these types of ?dinosaur advertising? have one thing that?s clearly lacking in this fast-paced world, and that is the ability? to immediately know what consumers out there are thinking about and talking about when it comes to their company, their products and, most of all, what their competitors are up to. In other words, in this day and age, data and analysis are needed in order to show you exactly what your ads are doing out there in cyberspace.

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Digital marketing centers are found all over the Internet. This has become THE best and only way of communication. Even when you look at magazines, more and more people are reading them online and not paying money for the ?hard copy.? Therefore, your stunning piece of advertising is more readily? seen on the Internet than it will ever be on the actual pages of an advertising vehicle you used to utilize.

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Reports may seem like a boring way to introduce companies to digital marketing, but reports are the truest way of data collection and being able to show clients everything from who?s reading what to who likes what. Even the negative comments are necessary to report in order for a company to see the issue quickly, identify problems, and fix them all as fast as possible.

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Not only that, but when a company goes sees that digital marketing and data collection are THE ways to go about increasing their ROI, then they also see that these database-driven online distribution channels are extremely cost-effective. Billions of marketing dollars that were spent on traditional marketing has shifted to digital marketing campaigns, and companies are saving money and building their client lists faster.

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You have to build a database of customers or potential customers as fast as possible. Solution: Digital Marketing. You need to find out how those customers prefer to be reached. Solution: Digital Marketing. And so on and so on. Companies need to understand the bottom line so that market share can increase, operational efficiencies can grow and automated marketing can be used in order to increase sales.

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Digital marketing is the biggest door that must be walked through when it comes to your bottom line, and the Be First Social Media team can walk you across that threshold and help your company become number one in your industry!

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For more information, head to:

www.befirstmediagroup.com

Source: http://staugnews.com/2012/10/29/social-media-is-the-bottom-line.html

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San Francisco gets ready for Giants' parade

San Francisco Giants fans celebrate outside PacBell Park on Sunday, Oct. 28, 2012, in San Francisco after the Giants swept baseball's World Series against the Detroit Tigers. (AP Photo/Noah Berger)

San Francisco Giants fans celebrate outside PacBell Park on Sunday, Oct. 28, 2012, in San Francisco after the Giants swept baseball's World Series against the Detroit Tigers. (AP Photo/Noah Berger)

A San Francisco Giants fan jumps over a bonfire in San Francisco's Mission district Sunday, Oct. 28, 2012, after the Giants swept the Detroit Tigers to win baseball's World Series. (AP Photo/Noah Berger)

San Francisco Giants fan David Zweig celebrates outside PacBell Park on Sunday, Oct. 28, 2012, in San Francisco after the Giants swept baseball's World Series against the Detroit Tigers. (AP Photo/Noah Berger)

San Francisco Giants fans celebrate outside San Francisco's City Hall while watching a broadcast of the Giants facing the Detroit Tigers in Game 4 of baseball's World Series on Sunday, Oct. 28, 2012. The Giants won the game to sweep the series. (AP Photo/Noah Berger)

San Francisco Giants fans celebrate outside PacBell Park on Sunday, Oct. 28, 2012, in San Francisco after the Giants swept baseball's World Series against the Detroit Tigers. (AP Photo/Noah Berger)

SAN FRANCISCO (AP) ? For the second time in three years, San Francisco is gearing up for a ticker-tape parade to celebrate a World Series victory for the Giants.

Plans for the Wednesday bash were being made as the city cleaned up after a rowdy celebration Sunday night turned violent in some neighborhoods and police arrested three dozen people.

"I'm not going to let the spirit of this city be destroyed by 36 people," Mayor Ed Lee said. "We're going to move forward with a great parade, a wonderful celebration."

The parade will take a slightly different route from the one that followed the Giants' 2010 championship. Instead of the financial district, it will start at the foot of Market Street.

The new route is safer and affords better views than the previous route, which followed a path taken in 1958 to introduce the Giants to San Francisco after their move from New York, Mayor's Office spokesman Francis Tsang said.

"A lot has changed since then," he added.

Regardless of the route, hundreds of thousands of fans are expected to turn out and rival the crowd that celebrated in 2010, when players, coaches and other luminaries rode in open-air buses designed to look like cable cars and vintage convertible cars.

Tens of thousands of people crowded into a park across the street from City Hall at the end of that parade to hear players, coaches and executives thank fans for their support.

This year, the parade occurs on Halloween, a historically notorious night for San Francisco, with landmarks such as Coit Tower and City Hall bathed in orange and black light.

In previous years, hundreds of thousands of revelers descended on the Castro neighborhood, and authorities struggled to control the crowds. After a shooting in 2006 wounded nine people, officials canceled the party and the night is now marked by a heavy police presence.

As some city workers were busy Monday erecting VIP stands in front of City Hall, others were sweeping up broken glass and charred debris left behind in the Mission District and other neighborhoods where the revelry turned violent after midnight.

The Police Department arrested 36 people, the majority in the Mission. Two were taken into custody on gun charges.

However, Sgt. Michael Andraychak said the vast majority of celebrations throughout the city, from the gay mecca of the Castro to touristy North Beach, were rowdy but peaceful. Fans doused each other with beer and champagne and danced in the streets, blocking motorists who happily honked their horns in celebration while stuck in gridlock.

"There were celebrations all over the city, and they were all peaceful and upbeat," Andraychak said. "Unfortunately, as the night progressed, this other element emerged and was intent on doing violence."

Bonfires of trash were lit in several intersections, and a $700,000 public transit bus was torched. Windows were broken out of several businesses and vehicles, including a news van.

Firefighters needed a police escort to douse a bonfire near the Giants' ball park. They also fought fires fueled by couches, news racks and other debris.

Police said a damage report was not yet available.

Police said most of the violence and damage occurred several hours after the last pitch and miles from Civic Center, where an estimated 10,000 peaceful fans watched the game on a giant Jumbotron television hastily erected by the city.

Mayor Lee said fans who watched the Giants endure six elimination games in the first two rounds of the playoffs before winning the World Series in four games "have a right to release that energy in a positive way."

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Staff writer Terry Collins in San Francisco contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-10-29-World%20Series-Giants%20Fans/id-0cbb26b0bf1f4cf8862c5f0b1bf7be69

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Superhumans

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Columbia's 24-Hour Night brings students ... - The Columbia Chronicle

David McEachin, senior art & design major and president of the Student Programming Board, rides the mechanical bulls, which were a new addition to Columbia?s annual 24-Hour Night at Stage Two in the 618 S. Michigan Ave. Building Oct. 25. Carolin Sanchez | THE CHRONICLE

Skinny jeans weren?t the only thing that caused chafing at Columbia?s annual 24-Hour Night, held Oct. 25?26.

The event, touted as ?Halloween, Columbia style,? was hosted by several student organizations and included a mechanical bull riding competition, a pumpkin carving contest, scary movie screenings and the Creepy Coming Out Ball sponsored by Common Ground, Columbia?s LGBTQ club.

Lynsey Mukomel, a marketing manager for the Student Programming Board, said the group tried to avoid confusion about the timing and location of events that plagued previous 24-Hour Nights. The indoor skating rink of the last two years was discontinued in favor of a ?The Halloween Hoedown? theme which gave them the idea for the mechanical bulls, which were located at Stage Two in the 618 S. Michigan Ave. Building.

?There is a competition level to it, which we find much more exciting,? Mukomel said. ?We think students showed up just to prove if they can stay on the longest.?

Students rode the bull, ate candy and had professional photos taken. Carlton Yarber, a junior interactive arts & media major, said he enjoyed the bull riding.

?It was pretty challenging,? Yarber said. ?The bull is slippery itself, so you have to go opposite the direction that the bull is going so that your can keep your balance.?

The crew of Columbia?s ?I Love the ?90s Tribute Show,? sponsored by the Humanities, History and Social Sciences Department, hosted a ?90s-themed event Oct. 26 that included a disc jockey spinning ?90s hits. Students were encouraged to dress in their best ?90s clothing.

?I told them that if we were going to do [a party on campus] we should do it as a part of 24-Hour Night,? said Oscar Valdez, administrative assistant and office manager in the Humanities, History and Social Sciences Department and an adviser to the event.

The Arts, Entertainment, and Media Management Department?s Club Management ? ? Practicum class also joined the campus fun by throwing a costume party at HAUS, the new student nightclub in the Quincy Wong Center, 623 S. Wabash Ave. The event titled Haunted HAUS, featured a? costume contest and a raffle for various prizes including a $10 gift card from their sponsor Cafecito.

According to Gigi Posejpal, director of International Student Affairs, its annual pumpkin carving event started long before it was a part of 24-Hour Night. This is the second year ISO joined the 24-Hour Night festivities, Posejpal said.

?[To share] U.S. culture and what we do for Halloween, the International Student Organization decided to start hosting a pumpkin carving contest,? Posejpal said.

Organizations choose to participate in 24-Hour Night to give students something fun and unique to do on campus and gain member traction, according to Mukomel.

?This is an alternative to students [who] don?t necessarily want to go all out with a costume and do the typical Halloween activities,? she said. ?At the same time, clubs can also put their name out there and show students what we do.?

To see a video of the event, visit ColumbiaChronicle.com.

Source: http://columbiachronicle.com/columbia%E2%80%99s-24-hour-night-brings-students-together-in-halloween-fashion/

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Business Travel Stress, Defined | Gadling.com

Business travel stress is caused by a number of reasons. Just being out of the office can make communication and keeping up with ongoing projects a challenge. Some travelers cope well with the challenges of working on the road. Others, not so much. A recent survey by Carlson Wagonlit Travel (CWT) polled more than 6,000 frequent business travelers from nine global corporations, and found that stress tends to fall into three categories.

Time lost when a traveler might be working but instead has to stand in a security line can add stress. Thinking "If I was in the office right now, I could be doing something productive" adds more stress.

Surprises caused by an unscheduled event that disrupts travel is another. Major storms with a cascading effect on airports not even in the affected area commonly add "Will I make my connection?" stress.

Routine breakers that cause an inability to stick to regularly scheduled home activities count too. Activities that are easy to do at home like exercising, watching television or surfing the web add stress when not done on the road.

The biggest stress factor of all? Lost Luggage.

"Losing one's baggage requires replacing the lost content, often in a short space of time. This presents multiple uncertainties under tight deadlines, which produced considerable stress," Carlson Wagonlit Travel (CWT) said in an Executive Travel article.

Coming in at number two on the list of 33 possible stress triggers was being without an Internet connection, or having an unreliable one. Third place was having to fly in coach on a medium or long-haul trip, followed by flight delays, inconvenient arrival or departure times, having to stay in a low-category hotel, inconvenient hotel locations, and last-minute travel.

[Photo Credit: Flickr user Samuel R?nnqvist]

Filed under: Business, North America, United States

Source: http://www.gadling.com/2012/10/29/business-travel-stress-defined/

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Verizon to sell Nokia phone

This Oct. 17, 2012, photo, shows a Verizon Wireless sign at a Little Rock, Ark.Verizon Wireless, the largest cellphone carrier in the U.S., said Monday, Oct. 29, 2012, it will sell a Nokia phone for the first time in years, lending support to the embattled Finnish company's turnaround effort. (AP Photo/Danny Johnston)

This Oct. 17, 2012, photo, shows a Verizon Wireless sign at a Little Rock, Ark.Verizon Wireless, the largest cellphone carrier in the U.S., said Monday, Oct. 29, 2012, it will sell a Nokia phone for the first time in years, lending support to the embattled Finnish company's turnaround effort. (AP Photo/Danny Johnston)

NEW YORK (AP) ? Verizon Wireless, the largest cellphone carrier in the U.S., says it will sell a Nokia phone for the first time in years, lending support to the embattled Finnish company's turnaround effort.

Verizon says it will sell the Lumia 822, an exclusive model that's part of Nokia's lineup of smartphones based on Microsoft's Windows software. Verizon didn't provide the launch date or price. Verizon rivals AT&T and T-Mobile USA started selling Lumia phones earlier this year.

Even though it was, until recently, the world's largest maker of phones, Nokia has been largely absent from the U.S. market for many years. Its early smartphones never caught on in the country, and it was virtually shut out once the iPhone launched in 2007.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2012-10-29-Nokia-Verizon%20Wireless/id-f2afc4ff0ee14ef0b30c185114d641f2

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Mechanism found for destruction of key allergy-inducing complexes, researchers say

ScienceDaily (Oct. 28, 2012) ? Researchers have learned how a synthetic molecule destroys complexes that induce allergic responses -- a discovery that could lead to the development of highly potent, rapidly acting interventions for a host of acute allergic reactions.

The study, published online Oct. 28 in Nature, was led by scientists at the Stanford University School of Medicine and the University of Bern, Switzerland.

The new inhibitor disarms IgE antibodies, pivotal players in acute allergies, by detaching the antibody from its partner in crime, a molecule called FcR. (Other mechanisms lead to slower-developing allergic reactions.)

"It would be an incredible intervention if you could rapidly disconnect IgE antibodies in the midst of an acute allergic response," said Ted Jardetzky, PhD, professor of structural biology and senior investigator for the study. It turns out the inhibitor used by the team does just that.

A myriad of allergens, ranging from ragweed pollen to bee venom to peanuts, can set off IgE antibodies, resulting in allergic reactions within seconds. The new inhibitor destroys the complex that tethers IgE to the cells responsible for the reaction, called mast cells. Severing this connection would be the holy grail of IgE-targeted allergy treatment.

The first time a potential allergen enters the body, some people respond by making allergen-specific IgE antibodies. These antibodies stick around long after the initial allergen is cleared from the body. Most of the antibodies get snagged by IgE-specific receptors called FcRs, which are exposed on the surface of mast cells. The mast cells are then primed to react the next time a person encounters the allergen.

Dissociation of this IgE-FcR interaction is a sought-after goal of allergy treatment for a good reason: IgE-coated mast cells are grenades of histamine, and re-encountering the allergen is equivalent to pulling out the clip. When an allergen makes a return visit, it binds to the pre-loaded IgE on the mast cell surface, triggering the release of inflammatory mediators -- including histamine -- that promote the allergic response. As allergy sufferers are well aware, these nasty reactions can occur within a matter of seconds. In a severe allergic response, sudden anaphylactic shock and death can be the result.

The key to actively disabling the allergic response lies in the separation of IgE from the FcRs on the surface of mast cells. But separating these dangerous couples is a tall order because their interaction is extremely stable -- sensitizing the mast cells for weeks. Currently available treatment using omalizumab (an anti-IgE antibody sold under the trade name Xolair) can block new interactions between IgE and FcR, but it is not designed to pry the molecules apart once they've formed a bond on the surface of a mast cell. So Xolair can dampen the allergic response, but as stated on the product's website: "Xolair is not a rescue medicine and should not be used to treat sudden asthma attacks."

While simply blocking IgE binding is helpful for some allergy sufferers, when it comes to the rapid quenching of an acute allergic response, "what you'd really like to do is get rid of it," said Jardetzky. Along with scientists at the University of Bern, his team discovered that an engineered protein inhibitor called DARPin E2-79 stripped IgE from the mast cell receptor. Using this inhibitor, "an interaction that normally lasts for hours or days in terms of its stability is stripped off in a matter of seconds," said Jardetzky.

DARPin E2-79 is one of a family of engineered inhibitors containing protein-binding regions called ankryin repeats. While Jardetzky's group was using structural biology and biophysical approaches to probe the weak spots in the IgE-FcR interaction, scientists at the University of Bern were tinkering with DARPins that dampened IgE's disastrous effects. The collaboration of the two groups resulted in the characterization of DARPin E2-79, an inhibitor that goes beyond mere blockade to actively disassemble the IgE-FcR power couple.

Jardetzky's group solved E2-79'S structure and used this information to model its interaction with the IgE-FcR pair. Then, using sensitive biochemical techniques that detect step-by-step binding interactions between molecules, the teams were able to tease out the mechanism that the inhibitor uses to break the IgE-FcR bond.

The researchers found that E2-79 hastens the separation of the two molecules by taking advantage of a moment of weakness in the relationship between IgE and FcR. IgE maintains its interaction with FcR using two contact points, and occasionally one of these points releases while the other one keeps the pair together. Normally this brief looseness isn't enough to separate the couple, but E2-79 can swoop into the small space between them, effectively driving the couple apart.

While E2-79 is the first molecule to display these IgE stripping characteristics, Jardetzky hopes that this work will stimulate the discovery of smaller compounds capable of working even more efficiently. Drug developers generally expect large macromolecules like E2-79 to be less potent than small molecule inhibitors and unlikely to be able to disrupt complexes, so the fact that E2-79 worked so well was a surprise. Small molecules are more amenable to oral administration, and are easier and cheaper to manufacture than large macromolecules. "Now we're in the hunt for a small molecule that could have this kind of activity. That would be the real hit," said Jardetzky.

The discovery of E2-79's mechanism of IgE inhibition could lead to rapid discoveries from other labs as well. Now that scientists know what mechanism to look for, they may be inspired to dig back through freezers full of IgE inhibitors that were identified years ago, said Jardetzky. In the light of techniques described in this study, perhaps once-neglected inhibitors will show new promise in the treatment of allergic disease.

The study's primary authorship was shared between Beomkyu Kim, PhD, a Stanford graduate student, and Alexander Eggel, PhD, at the University of Bern. The other Stanford co-author is research assistant Svetlana Tarchevskaya.

The study was funded by the National Institutes of Health, the American Asthma Foundation and the Swiss National Science Foundation.

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Story Source:

The above story is reprinted from materials provided by Stanford University Medical Center. The original article was written by Jessica Shugart.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Beomkyu Kim, Alexander Eggel, Svetlana S. Tarchevskaya, Monique Vogel, Heino Prinz, Theodore S. Jardetzky. Accelerated disassembly of IgE?receptor complexes by a disruptive macromolecular inhibitor. Nature, 2012; DOI: 10.1038/nature11546

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/SyVXKhtXvlw/121028142316.htm

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